Ii-microplastics zinokuphazamisa kakhulu ukusebenza kwee-phagocytes esibindini, ubuncinci kwiimpuku. Isiphumo kukuphazamiseka kokusebenza kwe-metabolic yesitho kunye nokugcinwa kwamafutha okwandisiweyo. Ezi ziziphumo eziphambili zophando lwaseJamani nase-Austria olukhokelwa yiYunivesithi yaseBonn, olupapashwe kwiphephancwadi i-Nature Metabolism. Ii-Phagocytes, okanye ii-macrophages, luhlobo olukhethekileyo lweeseli ezimhlophe zegazi. Zikhangela iibhaktheriya, iiseli zomzimba ezinesifo, kunye nezinto zangaphandle, zizigqume, kwaye ziwahlukanise zibe ziinxalenye zazo. "Kuye kwaziwa iminyaka ethile kwiinkcubeko zeeseli ukuba ii-macrophages nazo zitya ii-microplastics," ucacisa uNjingalwazi u-Elvira Mass wase-LIMES Institute kwiYunivesithi yaseBonn. "Besifuna ukwazi ukuba oku kunjalo nakwizinto eziphilayo kwaye oku kunaliphi ifuthe." Kunye namaqela ophando kwiYunivesithi yaseBonn nakwiSibhedlele seYunivesithi yaseBonn, ugxile kwiiseli zeKupffer, ii-macrophages ezikwi-sinusoids, imithambo yegazi emincinci yesibindi. Ukusuka apho, zijonga igazi elihamba kwinkqubo yokujikeleza kwegazi. Zonke iinxalenye zeplastiki ezifunxwa ngamathumbu kufuneka zidlule kuzo.
Iingcali ziqikelela ukuba abantu abadala batya ukuya kuthi ga kwiigram ezintlanu zeplastiki ngeveki, ubunzima obufana nobekhadi letyala. Iimpuku ezincinci zinobunzima obumalunga nama-gram angamashumi amabini kuphela, ngoko ke abaphandi balungisa umthamo ngokufanelekileyo. Kanye ngeveki, izilwanyana zazifumana amasuntswana alingana nebhaktheriya eqhelekileyo. Emva kweeveki ezilishumi elinambini, kwacaca ukuba iiseli zeKupffer zitye izixa ezikhulu zeeplastiki ezincinci, uxela uGqr. Nikola Makdissi, owenza olu vavanyo kunye noGqr. Maria Francesca Viola. Ngokwesiqhelo, ii-macrophages zigaya amaxhoba azo kwaye ziphinde zisebenzise izixhobo. Iplastiki iyamelana nezi ndlela zokunciphisa umzimba kwaye ivale "isisu" seeseli ze-phagocytic. Ezi seli azinakuyitya i-pathogens okanye iiseli ezineziphene, kwaye azinazo iibhloko ezibalulekileyo zokwakha imetabolism yazo. Iiseli zisabela ngokuvelisa ii-apolipoproteins, isignali yoxinzelelo lweemolekyuli. Ezinye iiseli zesibindi ziyayibona le signali kwaye ziqokelela amafutha amaninzi. Umsebenzi we-macrophage ophazamisekileyo ke ngoko ukhokelela kwisifo semetabolism yesibindi.
Iinxalenye ezinobukhulu beebhaktheriya zibonakala zinengxaki kakhulu. Iinxalenye ezincinci ngokuphindwe kalishumi zavala ii-phagocytes kakhulu kwaye zadlula kakhulu utshintsho olufunekayo kwisibindi. Endaweni yoko, zaqokelelana kwizicubu ezimdaka zamafutha, apho amafutha angagcinwa khona kodwa atshiswe ukuze kuveliswe ubushushu. Ii-nanoplastics zavuselela le ndlela kwiimpuku. Abaphandi ngoku baceba ukuphanda le mpembelelo ngokusondeleyo. Ukongeza kwiBonn kunye neSibhedlele seYunivesithi iBonn (UKB), iYunivesithi yeZibonelelo zeNdalo kunye neSayensi yoBomi, iTulln (BOKU), iYunivesithi yaseFriedrich-Alexander iErlangen-Nuremberg, iYunivesithi yaseVienna, kunye neYunivesithi yaseHamburg bathathe inxaxheba kolu phando. Inkxaso-mali yanikezelwa, phakathi kwezinye, yiGerman Research Foundation (DFG), iEuropean Research Council (ERC), kunye neAustrian Science Fund (FWF). Ukuba ezi ziphumo zingasetyenziswa ebantwini kuya kufuna uphando olongezelelweyo. Nangona kunjalo, olu phononongo lubonisa ukuba iplastiki ayiqokeleli nje emzimbeni kodwa inokuphazamisana nokusebenza kakuhle kweeseli zesibindi.
Ushicilelo lokuqala:
UNikola Makdissi nabanye: Ukuvezwa kweplastiki okuxhomekeke kubungakanani kuphazamisa ukusebenza kwe-macrophage kunye ne-metabolism ethile yezicubu; I-Nature Metabolism; I-DOI: 10.1038/s42255-026-01615-8; https://doi.org/10.1038/s42255-026-01615-8
