Odabeni lwakamuva lwe "Journal of the American Chemical Society," iqembu locwaningo eliholwa nguProf. UDkt Johannes Teichert (Chemnitz University of Technology, uMnyango we-Organic Chemistry), kanye nabalingani bocwaningo beqembu eliholwa nguProf. UDkt. Fabian Dielmann (University of Innsbruck, Department of Inorganic Chemistry), wethula imiphumela yocwaningo ku-copper catalyst entsha. Inoveli, "i-bifunctional" ye-catalyst molecule esekelwe ethusi iqukethe ama-subunits amabili futhi yenza i-hydrogenation yezinye izinhlanganisela, ngaleyo ndlela isebenze futhi idlulise i-molecule ye-hydrogen (H2).
"Eqinisweni, i-copper catalyst ivuselela i-hydrogen-thina eqenjini lethu locwaningo siye sacwaninga lolu hlobo lokuphinda kwenziwe kabusha isikhathi esithile. Kodwa-ke, lokhu ngokuvamile kwakudinga ukucindezela okuphezulu kwe-H2, okudinga ukusetshenziswa kwemikhumbi yokusabela kwe-high-pressure (autoclaves). Futhi lokho akunakwenzeka. Manje sithole ukuthi iyunithi yesibili ye-catalytically esebenzayo, i-iminopyridine i-aminopyridine esebenzayo, ukwenza i-aminopyridine i-aminopyridine engaphezulu, ukwenza i-aminopyridine i-coopper esebenzayo. ukuze ukusabela manje kwenzeke ngomfutho ophansi we-H2 webha engu-1 Lokhu kwenza indlela ibe lula ukuyisebenzisa elabhorethri,” kubika uTeichert. Ithimba lithembele ekwakhiweni kwe-catalyst evamile enezikhungo ezimbili ezihlukene ezisebenzayo.
I-catalyst entsha ibonisa ukusebenza kabusha okuphezulu kangangokuthi ngisho namaqembu angasebenzi angasasebenzi ngaphakathi kwama-molecule angaguqulwa ngokuphumelelayo. Lawa okuthiwa ama-enamide ngokuvamile ayizakhiwo zesakhiwo sezinto eziphilayo ngenxa yokuthi awasasebenzi. I-catalyst yethusi entsha manje yenza, ngokokuqala ngqa, i-hydrogenation ngokuqondile kulawa maqembu asebenzayo, ngaphambili ayebhekwa njengangasebenzi. Lokhu kungasetshenziselwa ukuguqulwa okuqhubekayo kwama-molecule ezidakamizwa. Umsebenzi wamanje ubonisa ukuthi inani elikhulu lama-molecule asetshenziswa kwezokwelapha lingaguqulwa ngale ndlela. "Eqinisweni, leli qhinga manje livula ithuba lokulebula kwe-isotopic, ngaphezu kokuhlukahluka okulula kwezithako ezisebenzayo ezaziwayo, uma i-deuterium, okungukuthi i-hydrogen esindayo, isetshenziswa esikhundleni se-hydrogen ngokwayo. Lokhu kubaluleke kakhulu ekucwaningweni kwezinqubo ze-biological futhi ikakhulukazi ezifundweni zokuwohloka kwezithako ezisebenzayo, "kusho uTeichert.
Lo msebenzi uwumphumela wokubambisana kwemingcele. "Eqinisweni, lesi yisibonelo esivamile socwaningo lwamangqamuzana oluhlanganyelwe: Esinye sezici ezimbili zokwakha i-catalyst sivela e-Chemnitz University of Technology, enye ivela e-Innsbruck," kusho uTeichert. "Besingalindele ukuthi le hybrid catalyst izosebenza kangaka." Umsebenzi manje wenza isisekelo seminye imiklamo yocwaningo eyenziwa yiqembu elisebenzayo lamazwe ngamazwe, isibonelo, ngaphakathi kwenethiwekhi yocwaningo ye-EU CATALOOP, eholwa nguTeichert. Ngokukaprofesa wamakhemikhali, ukuhlolwa kokulebula okukhulunywe ngenhla kuzophinde kuhlolwe.
Ukushicilelwa kwangempela
UMahadeb Gorai, uJonas H. Franzen, uPhilipp Rotering, uTobias Rüffer, uFabian Dielmann, uJohannes F. Teichert. I-Alkyne Semihydrogenation Esetshenziswa Kabanzi Esebenzisa I-Copper(I)-Catalyzed Semihydrogenation kanye ne-Hydrogenation ye-?,?-Unsaturated Amides Enikwe Amandla yi-Bifunctional Iminopyridine Ligands. Ijenali ye-American Chemical Society. Ephreli 16, 2025.
Funda futhi
