Kwiphepha lakutshanje le "Journal of the American Chemical Society," iqela lophando elikhokelwa nguProf. UDkt Johannes Teichert (iYunivesithi yaseChemnitz yeTekhnoloji, iSebe le-Organic Chemistry), kunye namaqabane ophando kwiqela elikhokelwa nguProf. Inoveli, "i-bifunctional" ye-copper-based catalyst molekyuli inee-subunits ezimbini kwaye yenza i-hydrogenation yezinye iikhompawundi, ngaloo ndlela isebenze kwaye idlulisele i-molecule ye-hydrogen (H2).
"Ngokomgaqo, i-copper catalyst ivuselela i-hydrogen-thina kwiqela lethu lophando siye saphanda ngolu hlobo lwe-reactivity kangangexesha elithile. Nangona kunjalo, oku kudla ngokufuna uxinzelelo oluphezulu lwe-H2, olufuna ukusetyenziswa kweenqanawa zokuphendula uxinzelelo oluphezulu (i-autoclaves). Kwaye oko akunakwenzeka. Ngoku siye safumanisa ukuba iyunithi yesibini esebenzayo, i-iminopyridine i-aminopyridine, i-aminopyridine i-aminopyridine, i-aminopyridine, i-aminopyridine i-autoclaves. ukuze impendulo ngoku yenzeke kuxinzelelo oluphantsi lwe-H2 lwebha ye-1. Iqela lixhomekeke kuyilo lwe-catalyst jikelele kunye namaziko amabini ahlukeneyo asebenzayo.
I-catalyst entsha ibonisa i-reactivity ephezulu kangangokuba namaqela asebenzayo angasebenziyo ngaphakathi kwee-molecules anokuguqulwa ngokufanelekileyo. Ezi zinto zibizwa ngokuba zii-enamides zihlala ziziibhloko zokwakha ezisebenza ngokwebhayoloji ngokuchanekileyo ngenxa yokuba zingasebenzi. I-catalyst entsha yobhedu ngoku yenza, ngokokuqala ngqa, i-hydrogenation ngqo kula maqela asebenzayo, awayebhekwa njengento engasebenziyo ngaphambili. Oku kungasetyenziselwa uhlengahlengiso olongezelelweyo lweemolekyuli zamachiza. Umsebenzi okhoyo ubonisa ukuba inani elikhulu leemolekyuli ezisetyenziselwa amayeza linokuguqulwa ngale ndlela. "Ngokomgaqo, esi sicwangciso ngoku sivula ithuba lokubhalwa kwe-isotopic, ukongeza kwi-diversification elula yezinto ezisebenzayo ezaziwayo, xa i-deuterium, oko kukuthi i-hydrogen enzima, isetyenziselwa endaweni ye-hydrogen ngokwayo. Oku kubaluleke kakhulu kuphando lweenkqubo ze-biological kwaye ngokukodwa kwizifundo zokuthotywa kwezinto ezisebenzayo, "kusho uTeichert.
Lo msebenzi usisiphumo sentsebenziswano enqumla imida. "Ngokomgaqo, lo ngumzekelo oqhelekileyo wophando oluhlangeneyo lwemolekyuli: Enye yeebhloko ezimbini zokwakha i-catalyst ivela kwiYunivesithi yaseChemnitz yeTekhnoloji, enye evela e-Innsbruck," kusho uTeichert. "Besingalindelanga ukuba le hybrid catalyst isebenze kangaka." Umsebenzi ngoku wenza isiseko seeprojekthi zophando ezongezelelweyo liqela elisebenzayo lamazwe ngamazwe, umzekelo, ngaphakathi kwenethiwekhi yophando ye-EU CATALOOP, ekhokelwa nguTeichert. Ngokukanjingalwazi wekhemistri, imifuniselo yokuleyibhela ekhankanywe ngasentla iya kuphononongwa ngakumbi.
Ushicilelo lokuqala
UMahadeb Gorai, uJonas H. Franzen, uPhilipp Rotering, uTobias Rüffer, uFabian Dielmann, uJohannes F. Teichert. I-Alkyne Semihydrogenation eSebenzayo ngokubanzi yeCopper(I)-Catalyzed kunye neHydrogenation ye-?,?-Unsaturated Amides enikwe amandla yiBifunctional Iminopyridine Ligands. Ijenali ye-American Chemical Society. Nge-16 ka-Epreli, 2025.
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